Homeotic transformations and limb defects in Hox A11 mutant mice.
نویسندگان
چکیده
منابع مشابه
Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice.
Homozygous mice mutated by homologous recombination for the AbdB-related Hoxa-10 gene are viable but display homeotic transformations of vertebrae and lumbar spinal nerves. Mutant males exhibit unilateral or bilateral criptorchidism due to developmental abnormalities of the gubernaculum, resulting in abnormal spermatogenesis and sterility. These results reveal an important role of Hoxa-10 in pa...
متن کاملExpression of Hox A11 in the limb and the regeneration blastema of adult newt.
Homeoproteins are functionally involved in pattern formation of developing systems and are potentially good candidates to regulate positional information during limb regeneration in the newt. Here we report the molecular structure of Hox A11 and its pattern of expression during the regeneration of adult newt appendages. The transcriptional unit of the gene is composed of two exons separated by ...
متن کاملHomeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid
Exposure of murine embryos to teratogenic doses of retinoic acid (RA) induced homeotic transformations of vertebrae. Posterior transformations occurred along the complete body axis after RA administration on day 7 of gestation and were accompanied by anterior shifts of Hox gene expression domains in embryos. Anterior transformations of vertebrae in the caudal half of the vertebral column were i...
متن کاملA mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression.
Valproate (VPA) is one of several effective anti-epileptic and mood-stabilizing drugs, many of which are also potent teratogens in humans and several other mammalian species. Variable teratogenicity among inbred strains of laboratory mice suggests that genetic factors influence susceptibility. While studying the genetic basis for VPA teratogenicity in mice, we discovered that parental factors i...
متن کاملAxial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11.
Using gene targeting, we have created mice with a disruption in the homeobox-containing gene hoxd-11. Homozygous mutants are viable and the only outwardly apparent abnormality is male infertility. Skeletons of mutant mice show a homeotic transformation that repatterns the sacrum such that each vertebra adopts the structure of the next most anterior vertebra. Defects are also seen in the bones o...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1993
ISSN: 0890-9369
DOI: 10.1101/gad.7.12a.2318